In guinea pigs, particles encourage persistent immune responses against the hollow mesoporous silica nanoparticles as the delivery vehicle of foot‐and‐mouth disease virus

2^nd World Congress Virology and Infectious disease

Date: September 3-4, 2019

Venue: London, UK

URL:  https://bit.ly/2q62wrS  

In guinea pigs, particles encourage persistent immune responses against the hollow mesoporous silica nanoparticles as the delivery vehicle of foot‐and‐mouth disease virus

Foot‐and‐mouth sickness (FMD) is associate acute and symptom communicable disease, which may cause nice economic losses.

Virus‐like particles (VLPs) as the associate advantageous matter will induce an important specific reaction.

To enhance immunity of VLPs, especially, create it induce a persistent reaction, the hollow mesoporous silicon oxide nanoparticles (HMSNs) as a possible nano‐adjuvant were synthesized and loaded the FMD virus (FMDV) VLPs.

They were injected into guinea pigs and therefore the specific reaction was detected.

The results confirmed that HMSNs/VLPs will induce persistent body substance immunity with high‐level protein concentration for over 3 months.

 HMSNs conjointly improve the T‐lymphocyte proliferation and IFN‐γ induced by FMDV VLPs and provides the perfect protection against FMDV challenge.

These consequences indicated that HMSNs were sensible macromolecule delivery vehicle and potential Nano‐adjuvant of vaccines.

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Contact details
Clara Charlotte
Program Manager | Virology 2019
Email:virology@microbioconferences.com

Phone: +44 20 3769 1755